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Degradation of coeliac diseaseâinducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells
Sat, 07/31/2010 - 17:00Summary (Source: Clinical and Experimental Immunology)
Categories: Celiac News
Lambliasis as Differential Diagnosis of MARSH Type 3b.
Sat, 07/31/2010 - 17:00Authors: Kasper HU, Kemper M, Siebert F, Langner C Giardia lamblia is the most common human parasite with a worldwide distribution and fecal-oral way of transmission. Diagnostic procedures include stool examination and gastroduodenoscopy with biopsy or secret aspiration. In most cases histology reveals a dense accumulation of the parasites on the surface of the duodenal mucosa with no or only slight inflammation. In rare cases, a dense inflammatory infiltrate with severe mucosal atrophy and increased count of intraepithelial lymphocytes may be seen. If in such cases the amount of parasites is low, the histological picture may mimic celiac disease. The two presented cases demonstrate the close morphological relationship and show the importance of considering giardiasis in the differenti...
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Categories: Celiac News
Celiac Disease Diagnosis Up 4-Fold Worldwide
Fri, 07/30/2010 - 21:52Improved diagnostic methods and treatments are on the horizon. Medscape Medical News (Source: Medscape Today Headlines)
Categories: Celiac News
Epidemiological Research Drives a Paradigm Shift in Complementary Feeding - The Celiac Disease Story and Lessons Learnt.
Thu, 07/29/2010 - 13:30Authors: Nordyke K, Olsson C, Hernell O, Ivarsson A Breast milk is the initial natural food for infants, but already during the second half year complementary feeding is essential. Epidemiological research, first on celiac disease and later on atopic diseases, has driven a paradigm shift with respect to most favorable age to introduce complementary feeding. Simplified, this implies a shift from later to earlier introduction, which is now taken into account in recommendations on infant feeding. Complementary feeding, including all foods, should not be initiated for any infant before 4 months of age, and not later than around 6 months, including infants with elevated disease risk (e.g. for celiac disease or atopic diseases). Motivating reasons could be that ongoing breastfeeding provides...
Categories: Celiac News
Psychosocial Factors Are More Important Than Disease Activity in Determining Gastrointestinal Symptoms and Health Status in Adults at a Celiac Disease Referral Center
Thu, 07/29/2010 - 10:07Conclusions In patients presenting to a CD referral center, psychosocial factors more strongly affect health status and GI symptoms than disease measures. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1342-yAuthors Spencer D. Dorn, University of North Carolina Center for Functional GI and Motility Disorders Chapel Hill NC USALincoln Hernandez, Tulane University Health Sciences Center Section of Gastroenterology and Hepatology, Department of Medicine New Orleans LA USAMaria T. Minaya, Celiac Disease Center at Columbia University New York NY USACarolyn B. Morris, University of North Carolina Center for Functional GI and Motility Disorders Chapel Hill NC USAYuming Hu, University of North Carolina Center for Functional GI and Motility Disord...
Categories: Celiac News
Celiac Disease Diagnosis: Simple Rules Are Better Than Complicated Algorithms
Tue, 07/27/2010 - 23:58Abstract: Celiac disease is the only treatable autoimmune disease, provided that a correct diagnosis is achieved and a strict, lifelong gluten-free diet is implemented. The current diagnostic algorithm for celiac disease includes initial screening serological tests, followed by a confirmatory small intestinal biopsy showing the autoimmune insult typical of celiac disease. The biopsy, considered the diagnostic gold standard, has been recently questioned as a reliable and conclusive test for every case. Indeed, the wide variability of celiac disease-related findings suggests that it is difficult to conceptualize the diagnostic process into rigid algorithms that do not always cover the clinical complexity of this disease. Instead we find clinically useful the shifting to a quantitative approa...
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Categories: Celiac News
Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease.
Tue, 07/27/2010 - 17:00Authors: van den Broeck HC, de Jong HC, Salentijn EM, Dekking L, Bosch D, Hamer RJ, Gilissen LJ, van der Meer IM, Smulders MJ Gluten proteins from wheat can induce celiac disease (CD) in genetically susceptible individuals. Specific gluten peptides can be presented by antigen presenting cells to gluten-sensitive T-cell lymphocytes leading to CD. During the last decades, a significant increase has been observed in the prevalence of CD. This may partly be attributed to an increase in awareness and to improved diagnostic techniques, but increased wheat and gluten consumption is also considered a major cause. To analyze whether wheat breeding contributed to the increase of the prevalence of CD, we have compared the genetic diversity of gluten proteins for the presence of two CD epitopes (G...
Categories: Celiac News
Celiac Disease: Evaluation with Dynamic Contrast-enhanced MR Imaging [GASTROINTESTINAL IMAGING]
Tue, 07/27/2010 - 10:26Study results suggest that dynamic evaluation of the bowel wall by using contrast-enhanced MR imaging can be an effective and reproducible way to show the inflammation state in celiac disease. (Source: Continuous Publishing articles)
Categories: Celiac News
Long wait for coeliac diagnosis
Tue, 07/27/2010 - 00:16Many people with gluten intolerance are left waiting more than decade for a proper diagnosis, research has shown (Source: Nursing in Practice)
Categories: Celiac News
Celiac disease: how complicated can it get?
Mon, 07/26/2010 - 16:09Abstract In the small intestine of celiac disease patients, dietary wheat gluten and similar proteins in barley and rye trigger an inflammatory response. While strict adherence to a gluten-free diet induces full recovery in most patients, a small percentage of patients fail to recover. In a subset of these refractory celiac disease patients, an (aberrant) oligoclonal intraepithelial lymphocyte population develops into overt lymphoma. Celiac disease is strongly associated with HLA-DQ2 and/or HLA-DQ8, as both genotypes predispose for disease development. This association can be explained by the fact that gluten peptides can be presented in HLA-DQ2 and HLA-DQ8 molecules on antigen presenting cells. Gluten-specific CD4+ T cells in the lamina propria respond to these peptides, a...
Categories: Celiac News
The Genetics of Celiac Disease: Moving Beyond DQ2 and DQ8
Mon, 07/26/2010 - 13:19Drs. Gil Melmed and Dermot McGovern comment on a recent study in Nature Genetics identifying new SNPs associated with susceptibility to celiac disease. Medscape Genomic Medicine (Source: Medscape Today Headlines)
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Categories: Celiac News
Widespread misdiagnosis of coeliac disease
Mon, 07/26/2010 - 02:40Over half of patients with coeliac disease have been originally misdiagnosed with irritable bowel syndrome, a new survey has found. (Source: Pulse)
Categories: Celiac News
A quarter of coeliac disease sufferers wait 11 YEARS to be diagnosed
Mon, 07/26/2010 - 01:57Nearly one in four people suffering from gluten intolerance visited their doctor for a decade or more before receiving an accurate diagnosis, research has revealed today. (Source: the Mail online | Health)
Categories: Celiac News
This Month in Gastroenterology
Sun, 07/25/2010 - 17:00Celiac disease is a well-recognized cause of malabsorptive diarrhea, which responds to a strict, gluten-free diet. Untreated symptomatic celiac disease is associated with substantial morbidity and increased mortality. The availability of noninvasive, serologic testing has revealed a higher prevalence of asymptomatic or minimally symptomatic celiac disease than previously appreciated. The impact of undiagnosed, and therefore untreated, celiac disease on morbidity or mortality is currently uncertain. (Source: Gastroenterology)
Categories: Celiac News
Celiacs Need Vitamins To Help Stave Off Bone Disease
Sat, 07/24/2010 - 01:00Children with celiac disease need to include certain must-have vitamins in their diets to stave off weak bones and osteoporosis, say researchers at the University of Alberta. A study of 43 children and teens from three to 18 years of age diagnosed with celiac disease showed that they also tended to have low bone density, likely due to poor intake and absorption of vitamins and minerals... (Source: Health News from Medical News Today)
Categories: Celiac News
Kids with celiac disease need outdoor play
Fri, 07/23/2010 - 18:56EDMONTON, Alberta, July 23 (UPI) -- Children with celiac disease should go outside and play, and take vitamins to ward off weak bones and osteoporosis, researchers in Canada advise. Canada - Alberta - Coeliac disease - Health - Conditions and Diseases (Source: Health News - UPI.com)
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Categories: Celiac News
[Celiac disease and idiopathic dilated cardiomyopathy: A fortuitous association?]
Thu, 07/22/2010 - 17:00Authors: Said Y, Fehri W, Lahidheb D, Trabelsi S, Haouala H, Najjar T PMID: 20656449 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Categories: Celiac News
Celiac disease culprits found
Thu, 07/22/2010 - 15:59The key parts of gluten that are toxic to people with celiac disease have been identified by Australian researchers. (Source: CBC | Health)
Categories: Celiac News
Vitamins needed to help celiacs stave off bone disease, researchers find
Thu, 07/22/2010 - 15:00Children with celiac disease need to include certain must-have vitamins in their diets to stave off weak bones and osteoporosis, say researchers. (Source: ScienceDaily Headlines)
Categories: Celiac News
Experts Identify Three Culprits for Gluten Allergy
Thu, 07/22/2010 - 13:36Researchers have identified three fragments in gluten that appear to trigger the autoimmune response in people with celiac disease. Reuters Health Information (Source: Medscape Medical News Headlines)
Categories: Celiac News
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