Medworm Celiac News

Type 1 Diabetics Have High Prevalence of Thyroid and Celiac Autoantibodies

Significant proportions of young patients with type 1 diabetes also have thyroid and celiac disease autoantibodies, a large study from Germany confirms. Reuters Health Information (Source: Medscape Medical News Headlines)

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Bone mineral density and importance of strict gluten-free diet in children and adolescents with celiac disease

Conclusion: Children and adolescents on not strict GFD are at increased risk for low BMD. We therefore recommend that BMD should be evaluated in patients with positive EMA. In addition, patients on strict GFD are at risk for low BMD because of low calcium intake or vitamin D deficiency. Therefore, strict GFD with recommended calcium intake and vitamin D supplementation during winter and spring should be encouraged in all children and adolescents with celiac disease. (Source: Bone)

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Bulb biopsies for the diagnosis of celiac disease in pediatric patients

Conclusions: We suggest examining 4 biopsy samples from the duodenal bulb and 4 from the descending duodenum to improve diagnostic accuracy of CD. (Source: Gastrointestinal Endoscopy)

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Haplotype Analysis Discriminates Genetic Risk for DR3-Associated Endocrine Autoimmunity and Helps Define Extreme Risk for Addison's Disease.

Conclusion: Extreme risk for AD, especially in multiplex families, is associated with haplotypic DR3 variants, in particular a portion (3.8) but not all of the conserved 3.8.1 haplotype. PMID: 20631027 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

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I thought wholemeal bread was healthy - then I found out it was poisoning me

Rose Alison is a coeliac. This means if she eats gluten (a protein found in wheat, rye, barley and oats) her body will attack itself. (Source: the Mail online | Health)

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Dietary glycosaminoglycans interfere in bacterial adhesion and gliadins-induced pro-inflammatory response in intestinal epithelial (Caco-2) cells.

This study evaluates the influence of glycosaminoglycans (GAGs) on bacterial adhesion and their contribution in the gliadins-induced inflammatory response. The adhesion of potential probiotic (Bifidobacterium longum CECT 7347 and Bifidobacterium bifidum CECT 7365), commensal (Escherichia coli and Bacteroides fragilis) and pathogenic (Salmonella enterica CECT 443 and Lysteria monocytogenes CECT 935) bacteria to mucin and Caco-2 cell cultures was determined. Gliadins were subjected to in vitro digestion (pepsin/pancreatin-bile), with/out GAGs, and the presence or not of cell suspensions of B. longum (10(8) CFU/ml). B. longum, E. coli, and L. monocytogenes, markedly interact with the high-sulphur containing fraction of GAGs. The GAGs reduced the gliadins-mediated production of interleukin-1be...

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Celiac disease-associated antibodies in patients with psoriasis and correlation with HLA Cw6

Etiopathology of psoriasis is not completely understood. Patients with psoriasis show elevated sensitivity to gluten. The aim of this study was to see the expression of celiac disease (CD)-associated antibodies gliadin IgA, gliadin IgG, and tissue transglutaminase IgA, and their correlation with HLA Cw6 in patients with psoriasis. The study comprised 56 patients with psoriasis and 60 healthy controls (HC). The levels of antibodies were detected by using ELISA technique and HLA Cw6 typing was carried out by microcytotoxicity method. HLA Cw6 was significantly expressed in psoriasis cases when compared with HC (P (Source: Journal of Clinical Laboratory Analysis)

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In Order To Diagnose Celiac Disease, Is Biopsy Avoidable?

Diagnosis of celiac disease is based on a characteristic enteropathy in an intestinal biopsy and evidence that these changes are gluten-triggered. The appropriate use of simpler and more accurate tools would add reliability to the diagnosis of celiac disease. Thus, the celiac disease-related serology might have a key role in defining new diagnostic standards for celiac disease. A research article published on July 7, 2010 in the World Journal of Gastroenterology addresses this question... (Source: Health News from Medical News Today)

Categories: Celiac News

Is biopsy avoidable on diagnosis of celiac disease?

(World Journal of Gastroenterology) A research team from Argentina explored the accuracy of all available serological markers in diagnosing the disorder in the theoretical context of avoiding the invasive intestinal biopsy. They found that the DGP/tTG Screen assay was the best initial test for suspected celiac disease. Combinations of assays might be able to diagnose celiac disease accurately, avoiding biopsy in almost 92 percent of subjects under study. (Source: EurekAlert! - Medicine and Health)

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Current methods to diagnose the unresponsive and complicated forms of coeliac disease.

Authors: Hadithi M, Peña AS Coeliac disease is a common disorder. Due to the protean manifestations of the disease and the often mild but indolent course, the diagnosis is often missed. The method to diagnose this in principle reversible disease after the introduction of a gluten-free diet has attracted the attention of several scientific disciplines to find the simplest and most patient-friendly test. This has resulted in a noticeable impact on the clinical practice next to a general increased awareness of its existence, its pathogenesis, its course and recent evidence of increased mortality. Amendments made in the diagnostic criteria of coeliac disease over the last half century have simplified the diagnosis. However, the aspect most relevant to the specialist in internal medicine...

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Pattern of lymph node metastases of esophageal squamous cell carcinoma based on the anatomical lymphatic drainage system

The recent anatomical studies of the esophagus showed that submucosal longitudinal lymphatic vessels connect to the superior mediastinal and the paracardial lymphatics and lymphatic routes to periesophageal nodes originate from the muscle layer. Using clinical data for lymph node metastasis, we verify these anatomical bases to clarify the rational areas of lymph node dissection in esophageal cancer surgery. Analysis was performed on 356 consecutive patients who underwent esophagectomy with three-field dissection. Patients were divided into those with tumor limited within the submucosal layer and those with tumor invading or penetrating the muscle layer. Frequency of node metastasis was compared according to supraclavicular, upper mediastinum, mid-mediastinum, lower mediastinum, perigastric...

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Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?

CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. PMID: 20593499 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

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Celiac Disease: The Endocrine Connection

Celiac disease (CD) is a permanent sensitivity to gluten (). It is manifested as a systemic autoimmune disorder characterized by mucosal damage in the small intestine following ingestion of gluten (). Historically, CD has been considered uncommon in the United States. The prevalence of CD in the general United States population is estimated to be between 0.5% and 1% (). In the pediatric population, children aged 2 1/2 to 15 years, the prevalence of CD is estimated at 3 to 13 per 1,000 children (). However, current knowledge suggests that CD is likely to be underdiagnosed because of the myriad of clinical presentations (). As of 2008, the current estimate of CD cases in the United States was 3 million, with fewer than 100,000 correctly diagnosed (). (Source: Journal of Pediatric Nursing)

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Confocal endomicroscopy in the evaluation of celiac disease

Endoscopy 2010; 42: 606-606DOI: 10.1055/s-0030-1255541© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Full text (Source: Endoscopy)

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Inflammatory bowel diseases, celiac disease, and bone.

Authors: Bianchi ML The article summarizes the current knowledge on the pathogenesis, clinical aspects and treatment of bone problems in the major inflammatory bowel diseases (Crohn's disease and ulcerative colitis) and celiac disease. It presents the physiological relationship between intestine and bone as well as the alterations determined by disease-disrupted intestinal integrity. Two hypotheses about the pathogenetic mechanisms of bone metabolism derangements and bone loss are discussed: the classical one, that indicates calcium malabsorption as the main culprit, and the new one, that emphasizes the role of inflammation. The article summarizes the available epidemiological data about osteopenia/osteoporosis and fragility fractures in these chronic intestinal diseases and presents t...

Categories: Celiac News

Celiac disease in first-degree relatives of patients.

CONCLUSION: Celiac disease prevalence in this group of relatives was high. All new cases identified were symptomatic or had associated conditions. In this group, there was a high frequency of individuals with positive serological tests, symptoms suggestive of celiac disease, and no evidence of villous atrophy in the intestinal mucosa. PMID: 20711550 [PubMed - in process] (Source: Jornal de Pediatria)

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Primary intestinal T cell lymphomas in Indian patients - In search of enteropathic T cell lymphoma.

Conclusion: ITCL are rare in Indian patients but do occur and comprise a mixture of the enteropathic and non-enteropathic subtypes. PMID: 20699502 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)

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Percutaneous Embolization of Periduodenal Varix Due to Portal Hypertension in a Patient With Kidney–Pancreas Transplantation: A Case Report

Abstract: Kidney–pancreas transplantation is a valid therapeutic option for patients with insulin-dependent diabetes mellitus. However, vascular complications associated with pancreas transplantation are not uncommon. Herein we have reported a 32-year-old woman with a history of insulin-dependent diabetes mellitus and celiac disease. She underwent liver transplantation for acute hepatitis. After 7 years, the patient developed end-stage kidney disease beginning hemodialysis and being listed for a kidney–pancreas transplantation, which was successfully performed when she was 29 years old with enteric diversion (Roux intestinal loop reconstruction). Five years after kidney–pancreas transplantation, she was admitted to our hospital with serious intestinal bleeding and poor liver function...

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Inconstancy of human sex ratios at birth

To the Editor: When human sex ratio (proportion male) at birth is categorized by some demographic variables (e.g., maternal age, paternal age, parity) it is, as confirmed by Ein-Mor et al. , “remarkably constant.” However, I have adduced evidence that sex ratio shows substantial variation when it is categorized by selected other variables (e.g., adverse paternal chemical exposures [dioxin, dibromochloropropane, fungicides, methylmercury, vinclozolin, borates, alcohol, and smoking]; paternal pathology [human leukocyte antigen B15 positivity, non-Hodgkin's lymphoma, testicular cancer, and hepatitis B status], and adverse paternal occupation/exposures [professional driving or diving, astronaut, and nonionizing radiation]) . Moreover, offspring sex ratio reportedly varies substantially (...

Categories: Celiac News

Prevalence of Celiac Disease among Blood Donors in Sistan and Balouchestan Province, Southeastern Iran.

CONCLUSION: The prevalence of celiac disease among the southeastern Iranian population is high and comparable with other parts of Iran as well as many other countries. PMID: 20597563 [PubMed - in process] (Source: Archives of Iranian Medicine)

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Categories: Celiac News